As AI is profoundly transforming our societies at an increasingly rapid pace, governments and legislators have a pivotal role in shaping its development for years to come. We are, indeed, witnessing a mushrooming of initiatives that seek to regulate AI to minimize its negative externalities, particularly in what is known as the “AI safety” debate. At the same time, a wide range of measures have been put forward to stimulate the development and use of AI, which takes into account the specificities of the local ecosystem- what is often referred to as the definition of a national “AI strategy”. This panel will illustrate and compare the approaches to these issues taken by 4 leading jurisdictions in Latin America, reflecting in particular on the main preoccupations behind the existing proposals, the varying degree of stakeholder participation, and their expected effectiveness.